(2R)-2-Amino-4-(tritylthio)butanoic acid, N-FMOC protected, N-{[(9H-Fluoren-9-y)lmethoxy]carbonyl}triphenyl-D-methionine
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)-amino)-4-(tritylthio)butanoic acid
CAS: 1007840-62-1
Molecular Formula: C38H33NO4S
(2R)-2-Amino-4-(tritylthio)butanoic acid, N-FMOC protected, N-{[(9H-Fluoren-9-y)lmethoxy]carbonyl}triphenyl-D-methionine - Names and Identifiers
(2R)-2-Amino-4-(tritylthio)butanoic acid, N-FMOC protected, N-{[(9H-Fluoren-9-y)lmethoxy]carbonyl}triphenyl-D-methionine - Physico-chemical Properties
| Molecular Formula | C38H33NO4S |
| Molar Mass | 599.74 |
| Density | 1.256±0.06 g/cm3(Predicted) |
| Boling Point | 780.1±60.0 °C(Predicted) |
| pKa | 3.84±0.10(Predicted) |
| Storage Condition | Sealed in dry,2-8°C |
| Sensitive | IRRITANT |
| MDL | MFCD05663440 |
(2R)-2-Amino-4-(tritylthio)butanoic acid, N-FMOC protected, N-{[(9H-Fluoren-9-y)lmethoxy]carbonyl}triphenyl-D-methionine - Introduction
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)-amino)-4-(tritylthio)butanoic acid is an organic compound with the chemical formula C42H35NO4S and a molecular weight of 653.8g/mol.
The compound is an efficient natural amino acid protective agent, which is commonly used in solid-phase synthesis of amine sulfurization reaction, amine protection and peptide synthesis. It has reversible amine protection, and the protecting group can be removed by a reducing agent after the reaction is completed.
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)-amino)-4-(tritylthio)butanoic acid can be synthesized by the following steps: first, 9H-fluorene is reacted with methyl formate to obtain 9-methoxyfluorene, and then it is reacted with methylene chloride formate, N-(((9H-fluoren-9-yl) methoxy)carbonyl) fluoren-9-ylmethanol is produced. Next, it is reacted with sulfur and sodium chloride to obtain N-(((9H-fluoren-9-yl) methoxy) carbonyl)-S-fluoren-9-yl. Finally, the fluorenylsulfur compound is subjected to a condensation reaction with tritylamine to obtain (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)-amino)-4-(tritylthio)butanoic acid.
Regarding safety information, due to the lack of sufficient research and data, relatively little is known about the toxicity and safety of this compound. Therefore, it is necessary to follow laboratory safety procedures, wear appropriate personal protective equipment, and avoid contact with skin, eyes or inhalation of aerosols during use. If you intend to use this compound in industrial production, it is recommended that necessary toxicity and safety assessments be carried out.
The compound is an efficient natural amino acid protective agent, which is commonly used in solid-phase synthesis of amine sulfurization reaction, amine protection and peptide synthesis. It has reversible amine protection, and the protecting group can be removed by a reducing agent after the reaction is completed.
(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)-amino)-4-(tritylthio)butanoic acid can be synthesized by the following steps: first, 9H-fluorene is reacted with methyl formate to obtain 9-methoxyfluorene, and then it is reacted with methylene chloride formate, N-(((9H-fluoren-9-yl) methoxy)carbonyl) fluoren-9-ylmethanol is produced. Next, it is reacted with sulfur and sodium chloride to obtain N-(((9H-fluoren-9-yl) methoxy) carbonyl)-S-fluoren-9-yl. Finally, the fluorenylsulfur compound is subjected to a condensation reaction with tritylamine to obtain (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)-amino)-4-(tritylthio)butanoic acid.
Regarding safety information, due to the lack of sufficient research and data, relatively little is known about the toxicity and safety of this compound. Therefore, it is necessary to follow laboratory safety procedures, wear appropriate personal protective equipment, and avoid contact with skin, eyes or inhalation of aerosols during use. If you intend to use this compound in industrial production, it is recommended that necessary toxicity and safety assessments be carried out.
Last Update：2024-04-10 22:29:15
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